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P50 (neuroscience)
In electroencephalography, the P50 is an event related potential occurring approximately 50 ms after the presentation of a stimulus, usually an auditory click. The P50 response is used to measure sensory gating, or the reduced neurophysiological response to redundant stimuli.
Research has found an abnormal P50 suppression in people with schizophrenia, making it an example of a biological marker for the disorder. Besides schizophrenia, abnormal P50 suppression has been found in patients with traumatic brain injury, recreational drug use, and post-traumatic stress disorder.
==Paired click test==
In a paired click test, one auditory click sound will be presented, followed by a second click approximately 200 ms after the first one. The second sound is considered redundant, and so a typical control showing normal sensory gating will produce a reduced response (in wave amplitude) to the second click. The suppression is measured as the percentage of amplitude decrease in response to the second click compared to the first click, with typical controls showing an approximately 80% decrease to the second stimulus.〔 This response is recorded at the scalp and represents a pre-attentive process of sensory gating.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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